COURSE
NR-565: Advanced Pharmacology Fundamentals
- Question: G-Protien coupled receptors and how they interact with drugs
- Question: What neurotransmitters are excitatory?
- Question: Which is the most common CYP enzyme in the body? What role does it play?
- Question: What is the clinical significance of being an ultra-rapid CYP2D6 metabolizer?
- Question: What would be the concern if a drug is a CYP450indicer? How that might affect the metabolism of other drug the patient is taking?
- Question: Explain the significance of a drug being an inhibitor of P-glycoprotein? (see text)
- Question: Significance of a VCORC1 mutation for patients taking warfarin?
- Question: What out text has to say about National Standards of Culturally and Linguistically Appropriate Services?
- Question: What are some differences in drug metabolism in Asian populations?
- Question: According to out text and U.S office of Minority Healthy, what are reasons for poor health outcome among African American?
- Question: Which pharmacokinetic factors exhibit racial differences?
- Question: Phase I and II metabolism
- Question: What is the significance of VCORC1 mutation?
- Question: Can you describe how new drugs are developed from the text?
- Question: Explain what it means if a drug is an antagonist?
- Question: What the terms efficacy and bioavailability mean?
- Question: What are potential adverse effects associated with BBs according to the text? What lab abnormalities can occur?
- Question: Why do BBs, and clonidine require tapers when discontinuing them?
- Question: What are the effects of stimulation of beta 2 receptors?
- Question: Another concern of BBs is the risk of bronchospasm
- Question: Considering ACEIs: what labs require monitoring? What can happen to potassium levels? Are they safe for young women who could be pregnant?
- Question: Choose a topic from the study outline to discuss for your faculty response?
- Question: Choose a topic from the study outline to discuss for your faculty response?
- Question: Can you choose a topic from the study outline to discuss for your faculty response?
- Question: Can you choose a topic from the study outline to discuss for your faculty response?
ANSWER
- G-Protien coupled receptors and how they interact with drugs
G-protein coupled receptors (GPCR) interact with drugs through 7 regions of proteins that span and innervate the cell membrane, and trap the molecule into the receptor site like an interwoven basket (Insel & Sriram, 2018). Drugs can then enter this space and interact with the GRCP. A specific interaction and binding with a site on one or more of the regions of proteins within the GPCR, and drugs bound with the GRCP can stimulate the release of G proteins that can interact with various effector proteins to create physiological responses within the body (Insel & Sriram, 2018). This process occurs through secondary messengers (such as cAMP) which creates the extracellular interactions produced by the drug binding to the GRCP.
- What neurotransmitters are excitatory?
amino acids such as glycine, aspartate, and glutamate are excitatory (Woo & Robinson, p.16, 2016).……please click the icon below to purchase the midterm review at $19